Rethinking clinical trials: change is coming.
نویسنده
چکیده
www.sciencemag.org SCIENCE VOL 334 9 DECEMBER 2011 1317 COVER Scanning electron micrograph of a female Anopheles stephensi mosquito, a transmitter of malaria (proboscis length: ~0.6 millimeters). To drive malaria eradication, new medicines that target all stages of the malaria life cycle are needed. In their study, Meister et al. used thousands of A. stephensi mosquitos to identify chemical classes with activity against the silent malaria liver stage. See page 1372.
منابع مشابه
Rethinking the Theory of Change for Health in All Policies; Comment on “Health Promotion at Local Level in Norway: The Use of Public Health Coordinators and Health Overviews to Promote Fair Distribution Among Social Groups”
This commentary discusses the interesting and surprising findings by Hagen and colleagues, focusing on the role of the public health coordinator as a Health in All Policies (HiAP) tool. The original article finds a negative association between the employment of public health coordinators in Norwegian municipalities and consideration of a fair distribution of social and economic resources betwee...
متن کاملRethinking the Appraisal and Approval of Drugs for Fracture Prevention
Background: In January 2014, the EMA's Pharmacovigilance Risk Assessment Committee recommended that strontium ranelate no longer be used for osteoporosis. However, EMA's Committee for Medicinal Products for Human Use decided to restrict its use rather than ban it. Starting from this fact, evidence of drugs for fracture prevention over the last 30 years was reviewed and lessons to be learnt from...
متن کاملCross-Sectional Analysis of Data from the U.S. Clinical Trials Database Reveals Poor Translational Clinical Trial Effort for Traumatic Brain Injury, Compared with Stroke
Traumatic brain injury (TBI) is an important public health problem, comparable to stroke in incidence and prevalence. Few interventions have proven efficacy in TBI, and clinical trials are, therefore, necessary to advance management in TBI. We describe the current clinical trial landscape in traumatic brain injury and compare it with the trial efforts for stroke. For this, we analysed all strok...
متن کاملO12: Off the Couch and Out the Door: Improving Treatment Through a Refined Understanding of Psychotherapeutic Change
State-of-the-art psychotherapy for anxiety disorders represents some of the most efficacious treatments in the mental health literature. Nevertheless, these treatments are not panacea. Too many patients drop out of treatment, response rates leave room for improvement, and residual symptomatology is common. The quest to improve therapy for patients suffering from mental disorders necessitates on...
متن کاملEliminating the "expensive" adjective for clinical trials.
In the TV game show Family Feud contestants are asked to fill in the blank for sentences or phrases, with the “right answers” coming from previously completed surveys. Some entries are easy, like “Don’t judge a book by its ____.” Others are less so, like “Prime ____.” If there were a medical version of Family Feud, an easy question, at least in contemporary times, would likely be “Expensive Cli...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Science
دوره 334 6061 شماره
صفحات -
تاریخ انتشار 2011